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http://en.wikipedia.org/wiki/Celebrex

Celecoxib is licensed for use in osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, ankylosing spondylitis and to reduce the number of colon and rectal polyps in patients with familial adenomatous polyposis. It was originally intended to relieve pain while minimizing the gastrointestinal adverse effects usually seen with conventional NSAIDs. In practice, its primary indication is in patients who need regular and long term pain relief: there is probably no advantage to using celecoxib for short term or acute pain relief over conventional NSAIDs, except in the situation where non-selective NSAIDs or aspirin cause cutaneous reactions (urticaria or "hives"). In addition, the pain relief offered by celecoxib is similar to that offered by paracetamol (acetaminophen).[1]
Fabricated efficacy studies

On March 11, 2009, Scott S. Reuben, former chief of acute pain at Baystate Medical Center, Springfield, Mass., revealed that data for 21 studies he had authored for the efficacy of the drug (along with others such as Vioxx) had been fabricated, the analgesic effects of the drugs being exaggerated. Dr. Reuben was also a former paid spokesperson for Pfizer. The retracted studies were not submitted to either the U.S. Food and Drug Administration or the European Union's regulatory agencies prior to the drug's approval. Pfizer issued a public statement declaring, "It is very disappointing to learn about Dr. Scott Reuben's alleged actions. When we decided to support Dr. Reuben's research, he worked for a credible academic medical center and appeared to be a reputable investigator." [2][3]
Availability

Pfizer sells celecoxib under the brand name Celebrex, and is available as oral capsules containing 50 mg, 100 mg, 200 mg or 400 mg of celecoxib.

Celecoxib is not currently available as a generic in the United States, because it is covered by unexpired Pfizer patents. However, in other countries, including India and the Philippines, it is legally available as a generic under the brand names Cobix', Celcoxx and Celexib.

XL Laboratories sells celecoxib under the brand name Selecap in Vietnam and the Philippines.
Dosing

The usual adult dose of celecoxib is 100 to 200 mg once or twice a day. The lowest effective dose should be used.

Celecoxib capsule
What is this medicine?

CELECOXIB is known as a COX-2 inhibitor, a drug that belongs to the non-steroidal anti-inflammatory drug (NSAID) class. It is used to reduce swelling and to treat pain. This medicine is commonly used for various types of joint and muscular conditions, such as arthritis. It may be also used for bone pain, dental pain, headaches, or painful monthly periods. It may also be used to reduce the number of colon or rectal polyps in certain people.
What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
asthma
coronary artery bypass graft (CABG) surgery within the past 2 weeks
drink more than 3 alcohol-containing drinks a day
heart disease or circulation problems like heart failure or leg edema (fluid retention)
high blood pressure
kidney disease
liver disease
stomach bleeding or ulcers
an unusual or allergic reaction to celecoxib, sulfa drugs, aspirin, other NSAIDs, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?

Take this medicine by mouth with a full glass of water. Take it with food if it upsets your stomach or if you take 400 mg at one time. Try to not lie down for at least 10 minutes after you take the medicine. Take the medicine at the same time each day. Do not take more medicine than you are told to take. Long-term, continuous use may increase the risk of heart attack or stroke.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medicine?

Do not take this medicine with any of the following medications:
cidofovir
methotrexate
other NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
pemetrexed

This medicine may also interact with the following medications:
alcohol
aspirin and aspirin-like drugs
diuretics
fluconazole
lithium
medicines for high blood pressure
steroid medicines like prednisone or cortisone
warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?

Tell your doctor or health care professional if your pain does not get better. Talk to your doctor before taking another medicine for pain. Do not treat yourself.

This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional.

Do not take medicines such as ibuprofen and naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.

This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can happen without warning symptoms and can cause death.
What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
black or bloody stools, blood in the urine or vomit
blurred vision
breathing problems
chest pain
nausea, vomiting
problems with balance, talking, walking
redness, blistering, peeling or loosening of the skin, including inside the mouth
unexplained weight gain or swelling
unusually weak or tired
yellowing of eyes, skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
constipation or diarrhea
dizziness
gas or heartburn
upset stomach

This list may not describe all possible side effects.
Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

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